CRY2

Across TCGA cell cohorts, CRY2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,051 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRY2-associated GO terms across cancer lineages are Negative regulation of autophagy, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with CRY2 in more than 16 cancer types. Because this analysis shows association rather than direction, both CRY2-to-partner and partner-to-CRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by CRY2-low versus CRY2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY2→partner) and Y-score (partner→CRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.069	+1.002	<.001	<.001	3	17
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.153	+1.127	<.001	<.001	3	16
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.153	+1.127	<.001	<.001	3	16
URINARY_TRACT	Copper ion export →	-0.171	-0.804	.009	.007	2	16
OESOPHAGUS	Regulation of nuclear receptor-mediated glucocorticoid signaling pathway →	+0.120	+1.131	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.052	+0.908	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,051 associations by consensus.

Negative regulation of autophagy by CRY2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →