CRY2

Across TCGA cell cohorts, CRY2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRY2-associated genes across cancer lineages are OR56A5, OR6B2, and ELOA3DP. Each is linked with CRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRY2-to-partner and partner-to-CRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by CRY2-low versus CRY2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY2→partner) and Y-score (partner→CRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
LARGE_INTESTINE	OR6B2 →	+0.026	+2.791	.001	.005	3	1
LARGE_INTESTINE	ELOA3DP →	+0.018	+2.688	.001	.008	3	1
LARGE_INTESTINE	HMX3 →	+0.538	+3.531	<.001	.007	3	1
LARGE_INTESTINE	TAS2R30 →	+0.122	+3.273	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3 →	+0.049	+2.688	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR56A5 by CRY2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →