Q-omics provides the consensus-scored TBC1D3 profile across patient tissues and cancer cell-line models. TBC1D3 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, TBC1D3 is differentially expressed in 1, with the highest sampling consensus in KIRC. Additionally, TBC1D3 RNA expression shows 1,347 significant pathway-activity associations, with the highest sampling consensus in COAD. Together, these results highlight KIRP, KIRC, and COAD as cancer lineages where TBC1D3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TBC1D3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TBC1D3 survival associations across molecular data types. TBC1D3 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TBC1D3 RNA expression–survival associations across cancer types. High TBC1D3 expression shows unfavorable associations in KIRP, COAD, BRCA, LIHC and SKCM, but favorable associations in BLCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify KIRP as the clearest survival context for TBC1D3 RNA expression.
This table summarizes TBC1D3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for TBC1D3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TBC1D3 shows higher tumor expression in KIRC. The KIRC box plot shows higher TBC1D3 RNA expression in tumor versus normal tissue (log2 FC = +0.017, t-test p = .031).
This table shows molecular features associated with TBC1D3 in patient tissues and cancer cell lines. In patient samples, TBC1D3 shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set. In cancer cell lines, TBC1D3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in CNS and LARGE_INTESTINE.
