TBC1D3

Across TCGA cell cohorts, TBC1D3 RNA expression is significantly associated with the mutation status of many other genes, with 315 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D3-associated genes across cancer lineages are LCT, NUP98, and RBBP4. Each is linked with TBC1D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D3-to-partner and partner-to-TBC1D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCT grouped by TBC1D3-low versus TBC1D3-high in LUNG_NSCLC_LUSC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3→partner) and Y-score (partner→TBC1D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LCT →	+4.108	+0.470	.005	.005	3	2
SKIN	NUP98 →	+3.297	+0.780	.002	<.001	3	2
SKIN	RBBP4 →	+4.467	+0.740	.004	<.001	3	2
LARGE_INTESTINE	CCDC180 →	+1.813	+0.039	.006	<.001	3	2
LARGE_INTESTINE	C2orf81 →	+3.009	+0.066	.001	<.001	3	2
LARGE_INTESTINE	XIAP →	+4.273	+0.080	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 315 associations by consensus.

LCT by TBC1D3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →