TBC1D3

Across TCGA cell cohorts, TBC1D3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TBC1D3-associated genes across cancer lineages are ATXN3L, SSX7, and OR9K2. Each is linked with TBC1D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D3-to-partner and partner-to-TBC1D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATXN3L grouped by TBC1D3-low versus TBC1D3-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3→partner) and Y-score (partner→TBC1D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATXN3L →	+0.302	+4.459	.008	.001	3	1
LIVER	SSX7 →	+0.038	+3.977	.003	.006	3	1
OESOPHAGUS	OR9K2 →	+0.178	+4.017	.002	.007	3	1
OESOPHAGUS	TCP10L3 →	+0.052	+4.857	.002	<.001	3	1
OESOPHAGUS	PPP4R3C →	+0.006	+4.017	<.001	.007	3	1
PANCREAS	OR1L6 →	+0.019	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATXN3L by TBC1D3 expression — LIVER

Explore this box plot interactively →