CRY2

Across TCGA patient cohorts, CRY2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRY2-associated genes across cancer lineages are EGFR_pY1173, ERK2, and Lck. Each is linked with CRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRY2-to-partner and partner-to-CRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CRY2-low versus CRY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY2→partner) and Y-score (partner→CRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.066	+1.874	.025	.004	3	2
UCEC	ERK2 →	+0.162	+2.584	.022	.010	3	2
UCEC	Lck →	+0.149	+1.502	.043	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.763	+1.847	<.001	.008	3	2
UCEC	FOXO3a_pS318_S321 →	-0.093	-1.797	.041	.025	3	1
UCEC	JNK2 →	+0.286	+2.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1173 by CRY2 expression — UCEC

Explore this box plot interactively →