cyclin and CBS domain divalent metal cation transport mediator 4Genealiases: ACDP4 · SLC70A4
Q-omics provides the consensus-scored CNNM4 profile across patient tissues and cancer cell-line models. CNNM4 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, CNNM4 is differentially expressed in 13, with the highest sampling consensus in COAD. Additionally, CNNM4 RNA expression shows 20,561 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and COAD as cancer lineages where CNNM4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CNNM4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CNNM4 survival associations across molecular data types. CNNM4 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CNNM4 RNA expression–survival associations across cancer types. High CNNM4 expression shows unfavorable associations in ACC, LIHC, UCEC, KICH and LUSC, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for CNNM4 RNA expression.
This table summarizes CNNM4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 6. The strongest signals are observed in COAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for CNNM4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CNNM4 shows lower tumor expression in COAD and THCA and higher tumor expression in KIRP, LIHC, STAD and PAAD. The COAD box plot shows higher CNNM4 RNA expression in normal versus tumor tissue (log2 FC = −1.429, t-test p < 0.001).
This table shows molecular features associated with CNNM4 in patient tissues and cancer cell lines. In patient samples, CNNM4 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, CNNM4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and SOFT_TISSUE.
