CNNM4

Across TCGA cell cohorts, CNNM4 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNNM4-associated genes across cancer lineages are TAS1R2, SLC5A4, and HPCAL4. Each is linked with CNNM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNNM4-to-partner and partner-to-CNNM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS1R2 grouped by CNNM4-low versus CNNM4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM4→partner) and Y-score (partner→CNNM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TAS1R2 →	+0.014	+5.058	<.001	<.001	3	2
BLOOD_Leukemia	SLC5A4 →	+0.307	+3.345	<.001	.009	3	1
BLOOD_Leukemia	HPCAL4 →	+0.200	+3.478	.002	.006	3	1
BLOOD_Leukemia	NPPB →	+0.106	+3.662	<.001	.003	3	1
BLOOD_Leukemia	BTBD16 →	+0.069	+3.281	<.001	.003	3	1
BLOOD_Leukemia	ZIC5 →	+0.680	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

TAS1R2 by CNNM4 expression — CNS

Explore this box plot interactively →