CNNM4

Across TCGA cell cohorts, CNNM4 mutation is significantly associated with the mutation status of many other genes, with 5,044 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNNM4-associated genes across cancer lineages are UGGT1, ABCA2, and SULF2. Each is linked with CNNM4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CNNM4-to-partner and partner-to-CNNM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGGT1 grouped by CNNM4-low versus CNNM4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM4→partner) and Y-score (partner→CNNM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UGGT1 →	+2.655	+4.113	.009	.009	1	5
BLOOD_Leukemia	ABCA2 →	+2.247	+3.198	.001	.001	1	4
CNS	SULF2 →	+5.277	+4.459	.005	.005	1	4
STOMACH	WNK3 →	+4.807	+4.807	.008	.008	1	4
BLOOD_Leukemia	HDAC7 →	+4.399	+4.167	<.001	<.001	1	4
BREAST	FN1 →	+4.297	+4.857	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,044 associations by consensus.

UGGT1 by CNNM4 expression — SKIN

Explore this box plot interactively →