CNNM4

Across TCGA patient cohorts, CNNM4 mutation is significantly associated with the RNA expression of many other genes, with 3,845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNNM4-associated genes across cancer lineages are MAP1LC3B2, ZPR1, and C11orf58. Each is linked with CNNM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNNM4-to-partner and partner-to-CNNM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP1LC3B2 grouped by CNNM4-low versus CNNM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM4→partner) and Y-score (partner→CNNM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1LC3B2 →	+0.231	+2.807	.006	.003	3	3
UCEC	ZPR1 →	+0.418	+2.214	<.001	<.001	3	3
UCEC	C11orf58 →	+0.338	+1.950	.009	.008	3	3
UCEC	EIF2B2 →	+0.432	+1.769	<.001	<.001	3	3
UCEC	SSR1 →	+0.391	+2.043	<.001	.004	3	3
UCEC	HACL1 →	+0.480	+1.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,845 associations by consensus.

MAP1LC3B2 by CNNM4 expression — UCEC

Explore this box plot interactively →