CNNM4

Across TCGA pan-cancer cohorts, CNNM4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CNNM4 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CNNM4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CNNM4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where CNNM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.251	0.865	<.001	79	view →
PDAC	DFS	Tertile	II,III,IV	0.276	0.503	.018	10	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.910	.047	6	view →
UCEC	DFS	Median	All	0.847	0.955	.020	4	view →
LUAD	DFS	Median	III,IV	0.687	0.360	.020	4	view →
LSCC	DFS	Median	All	0.615	0.929	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CNNM4–CCRCC (OS)

Open the CCRCC breakdown →