CNNM4

Across TCGA patient cohorts, CNNM4 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNNM4-associated genes across cancer lineages are Src_pY527, S6, and FOXO3a_pS318_S321. Each is linked with CNNM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNNM4-to-partner and partner-to-CNNM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by CNNM4-low versus CNNM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM4→partner) and Y-score (partner→CNNM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.355	-2.115	.008	.016	3	3
STAD	S6 →	+0.467	+2.849	.038	.034	3	2
UCEC	FOXO3a_pS318_S321 →	-0.102	-1.727	.009	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.157	-1.571	.003	.005	3	2
UCEC	mTOR_pS2448 →	-0.134	-1.986	.004	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.389	-2.087	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Src_pY527 by CNNM4 expression — UCEC

Explore this box plot interactively →