Q-omics provides the consensus-scored CIAO3 profile across patient tissues and cancer cell-line models. CIAO3 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CIAO3 is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, CIAO3 RNA expression shows 17,468 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight HNSC, COAD, and ACC as cancer lineages where CIAO3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CIAO3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CIAO3 survival associations across molecular data types. CIAO3 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CIAO3 RNA expression–survival associations across cancer types. High CIAO3 expression shows unfavorable associations in LIHC, LGG, ACC and KICH, but favorable associations in HNSC and READ. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify HNSC as the clearest survival context for CIAO3 RNA expression.
This table summarizes CIAO3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in COAD for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CIAO3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CIAO3 shows higher tumor expression in COAD, LIHC, KIRP, STAD, LUAD and BRCA. The COAD box plot shows higher CIAO3 RNA expression in tumor versus normal tissue (log2 FC = +0.421, t-test p < 0.001).
This table shows molecular features associated with CIAO3 in patient tissues and cancer cell lines. In patient samples, CIAO3 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, CIAO3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
