CIAO3

Across TCGA pan-cancer cohorts, CIAO3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CIAO3 data layer compared with 16 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CIAO3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CIAO3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where CIAO3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
LUAD	OS	Median	II,III,IV	0.893	0.453	.026	9	view →
CCRCC	OS	Tertile	II,III,IV	0.985	0.133	.027	9	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	8	view →
LSCC	DFS	Tertile	III,IV	0.491	1.000	.009	7	view →
COAD	DFS	Quartile	II,III,IV	0.810	1.000	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CIAO3–PDAC (OS)

Open the PDAC breakdown →