CIAO3

Across TCGA cell cohorts, CIAO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,507 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIAO3-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with CIAO3 in more than 13 cancer types. Because this analysis shows association rather than direction, both CIAO3-to-partner and partner-to-CIAO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by CIAO3-low versus CIAO3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO3→partner) and Y-score (partner→CIAO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Symbiont-mediated disruption of host cell PML body →	+0.104	+0.606	.006	.001	3	14
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.179	+0.859	.002	.005	3	13
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.246	+0.579	<.001	<.001	3	13
URINARY_TRACT	Methylglyoxal metabolic process →	+0.142	+0.892	<.001	<.001	3	13
BONE	DNA double-strand break processing involved in repair via single-strand annealing →	+0.101	+0.620	<.001	<.001	3	12
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.129	-1.263	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,507 associations by consensus.

Symbiont-mediated disruption of host cell PML body by CIAO3 expression — LUNG_SCLC

Explore this box plot interactively →