CIAO3

Across TCGA patient cohorts, CIAO3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIAO3-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with CIAO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIAO3-to-partner and partner-to-CIAO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CIAO3-low versus CIAO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO3→partner) and Y-score (partner→CIAO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.399	+3.584	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.309	-3.807	<.001	<.001	3	2
UCEC	ERK2 →	+0.203	+2.700	.002	.005	3	2
UCEC	GAPDH →	+0.496	+2.415	.008	.002	3	2
UCEC	eIF4E →	+0.196	+3.598	.008	.001	3	1
UCEC	eIF4G →	+0.252	+1.874	.021	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eEF2 by CIAO3 expression — UCEC

Explore this box plot interactively →