CIAO3

Across TCGA pan-cancer cohorts, CIAO3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CIAO3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CIAO3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CIAO3 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where CIAO3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CIAO3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.360	<.001	9	view →
LSCC	Female	All	+0.209	<.001	7	view →
COAD	Female	II,III,IV	−0.269	<.001	6	view →
HNSC	All	II,III,IV	−0.103	.006	6	view →
CCRCC	All	All	−0.075	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CIAO3–LUAD

Open the LUAD breakdown →