chromosome 12 open reading frame 60Genealiases: []
Q-omics provides the consensus-scored C12orf60 profile across patient tissues and cancer cell-line models. C12orf60 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, C12orf60 is differentially expressed in 13, with the highest sampling consensus in THCA. Additionally, C12orf60 RNA expression shows 18,827 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and THCA as cancer lineages where C12orf60 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C12orf60 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C12orf60 survival associations across molecular data types. C12orf60 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (2) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C12orf60 RNA expression–survival associations across cancer types. High C12orf60 expression shows unfavorable associations in UVM, but favorable associations in ACC, UCS, KIRC, OV and THCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for C12orf60 RNA expression.
This table summarizes C12orf60 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 1. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for C12orf60. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C12orf60 shows lower tumor expression in THCA, KICH and LUAD and higher tumor expression in HNSC, COAD and LIHC. The THCA box plot shows higher C12orf60 RNA expression in normal versus tumor tissue (log2 FC = −0.876, t-test p < 0.001).
This table shows molecular features associated with C12orf60 in patient tissues and cancer cell lines. In patient samples, C12orf60 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C12orf60 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
