C12orf60

Across TCGA pan-cancer cohorts, C12orf60 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of C12orf60’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C12orf60 RNA is repressed in tumor relative to normal tissue. In most cancer types C12orf60 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and HNSC are the cancer types where C12orf60 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf60 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.876	<.001	11	view →
KICH	Male	All	−0.734	<.001	9	view →
HNSC	All	III,IV	+0.211	.001	9	view →
COAD	Male	All	+0.307	<.001	6	view →
LIHC	Male	All	+0.411	<.001	5	view →
LUAD	Female	III,IV	−0.404	<.001	5	view →
BRCA	All	All	+0.218	.004	4	view →
BLCA	All	All	+0.226	.015	3	view →
STAD	All	All	+0.226	.003	3	view →
CHOL	All	All	+0.866	.005	2	view →
PRAD	All	All	+0.534	<.001	2	view →
KIRP	All	All	−0.364	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

C12orf60–THCA

Open the THCA breakdown →