C12orf60

Across TCGA patient cohorts, C12orf60 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf60-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and MAPK_pT202_Y204. Each is linked with C12orf60 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf60-to-partner and partner-to-C12orf60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by C12orf60-low versus C12orf60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf60→partner) and Y-score (partner→C12orf60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.119	-3.169	.039	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-3.169	.014	.019	3	1
UCEC	MAPK_pT202_Y204 →	-0.568	-2.986	.012	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.342	-3.169	.009	.019	3	1
UCEC	MEK1 →	+0.394	+3.169	.025	.019	3	1
UCEC	PDCD4 →	-0.467	-2.990	.040	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

A-Raf_pS299 by C12orf60 expression — UCEC

Explore this box plot interactively →