Across TCGA pan-cancer cohorts, C12orf60 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of C12orf60’s most consistent transcriptional readouts.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where C12orf60 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf60 is over-expressed in tumor.
CCRCC are the cancer types where C12orf60 tumor–normal differential expression is most reproducible.