Q-omics provides the consensus-scored WDR74 profile across patient tissues and cancer cell-line models. WDR74 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, WDR74 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, WDR74 protein abundance shows 34,622 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, KIRC, and LSCC as cancer lineages where WDR74 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR74 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR74 survival associations across molecular data types. WDR74 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (3) and mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR74 RNA expression–survival associations across cancer types. High WDR74 expression shows unfavorable associations in ACC, KICH, KIRP, LIHC, UCEC and PAAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for WDR74 RNA expression.
This table summarizes WDR74 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for WDR74. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR74 shows higher tumor expression in KIRC, COAD, BLCA, STAD, LIHC and LUSC. The KIRC box plot shows higher WDR74 RNA expression in tumor versus normal tissue (log2 FC = +0.772, t-test p < 0.001).
This table shows molecular features associated with WDR74 in patient tissues and cancer cell lines. In patient samples, WDR74 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR74 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Lymphoma.
