WDR74

Across TCGA pan-cancer cohorts, WDR74 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of WDR74’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WDR74 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR74 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where WDR74 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR74 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.772	<.001	12	view →
COAD	Female	All	+1.614	<.001	11	view →
BLCA	Male	III,IV	+0.924	<.001	11	view →
STAD	Male	II,III,IV	+1.078	<.001	9	view →
LIHC	Male	II,III,IV	+0.984	<.001	9	view →
LUSC	Male	III,IV	+1.187	<.001	8	view →
HNSC	Male	III,IV	+0.911	<.001	8	view →
LUAD	Female	III,IV	+0.591	<.001	8	view →
KIRP	All	II,III,IV	+0.476	.003	7	view →
CHOL	Female	All	+1.710	<.001	5	view →
THCA	All	II,III,IV	+0.295	.004	4	view →
READ	Female	All	+0.890	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

WDR74–KIRC

Open the KIRC breakdown →