WDR74

Across TCGA pan-cancer cohorts, WDR74 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR74 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WDR74 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR74 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where WDR74 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.498	0.873	<.001	83	view →
COAD	DFS	Median	All	1.000	0.888	.023	42	view →
LSCC	DFS	Quartile	II,III,IV	0.903	0.442	<.001	33	view →
LUAD	DFS	Quartile	II,III,IV	0.798	0.360	.010	17	view →
PDAC	DFS	Quartile	III,IV	0.271	0.645	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR74–CCRCC (OS)

Open the CCRCC breakdown →