WDR74

Across TCGA patient cohorts, WDR74 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible WDR74-associated genes across cancer lineages are UBTFL3, RN7SL340P, and H3P46. Each is linked with WDR74 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR74-to-partner and partner-to-WDR74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBTFL3 grouped by WDR74-low versus WDR74-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR74→partner) and Y-score (partner→WDR74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UBTFL3 →	+0.016	+4.219	<.001	.006	3	2
SKCM	RN7SL340P →	+0.079	+3.748	<.001	.002	3	2
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
BRCA	MIR3689D2 →	+0.552	+8.055	<.001	.007	3	1
SKCM	WFDC10B →	+0.495	+3.414	<.001	.007	3	1
SKCM	SPANXN3 →	+0.187	+2.711	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

UBTFL3 by WDR74 expression — SKCM

Explore this box plot interactively →