H3P46

Q-omics provides the consensus-scored H3P46 profile across patient tissues and cancer cell-line models. H3P46 expression is associated with patient survival in 5 of 34 cancer types, with the highest sampling consensus in UCEC. Additionally, H3P46 RNA expression shows 5,639 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UCEC, and STAD as cancer lineages where H3P46 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes H3P46 survival associations across molecular data types. H3P46 RNA expression shows survival associations in the most cancer types (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

H3P46 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	5	UCEC (96)	view →

This table ranks reproducible H3P46 RNA expression–survival associations across cancer types. High H3P46 expression shows unfavorable associations in UCEC, THCA, ESCA, LAML and BRCA. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for H3P46 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.710	0.930	<.001	96	view →
THCA	OS	Tertile	All	0.188	0.942	<.001	90	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
LAML	DFS	Tertile	All	0.180	0.588	.014	18	view →
BRCA	DFS	Tertile	All	0.176	0.527	.015	12	view →

Pink = unfavorable, green = favorable. all 5 lineages →

H3P46-UCEC (OS)

Explore this curve interactively →