H3P46

Across TCGA pan-cancer cohorts, H3P46 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated H3P46 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher H3P46 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P46 expression acts as an unfavorable survival marker.

UCEC, THCA, and ESCA are the cancer types where H3P46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.710	0.930	<.001	96	view →
THCA	OS	Tertile	All	0.188	0.942	<.001	90	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
LAML	DFS	Tertile	All	0.180	0.588	.014	18	view →
BRCA	DFS	Tertile	All	0.176	0.527	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H3P46–UCEC (OS)

Open the UCEC breakdown →