WDR74

Across TCGA cell cohorts, WDR74 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible WDR74-associated genes across cancer lineages are OR8B12, OR8A1, and OR10D3. Each is linked with WDR74 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR74-to-partner and partner-to-WDR74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by WDR74-low versus WDR74-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR74→partner) and Y-score (partner→WDR74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B12 →	+0.054	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.447	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.119	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR8B3 →	+0.036	+4.371	.002	.005	3	1
LUNG_NSCLC_LUAD	OR8B2 →	+0.087	+5.189	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR8B12 by WDR74 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →