Q-omics provides the consensus-scored WDR70 profile across patient tissues and cancer cell-line models. WDR70 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, WDR70 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, WDR70 protein abundance shows 23,038 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KICH, HNSC, and GBM as cancer lineages where WDR70 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR70 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR70 survival associations across molecular data types. WDR70 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR70 RNA expression–survival associations across cancer types. High WDR70 expression shows unfavorable associations in KICH, LIHC and MESO, but favorable associations in READ, KIRC and UCS. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify KICH as the clearest survival context for WDR70 RNA expression.
This table summarizes WDR70 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for WDR70. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR70 shows higher tumor expression in HNSC, KIRC, LIHC, LUAD, LUSC and STAD. The HNSC box plot shows higher WDR70 RNA expression in tumor versus normal tissue (log2 FC = +0.601, t-test p < 0.001).
This table shows molecular features associated with WDR70 in patient tissues and cancer cell lines. In patient samples, WDR70 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR70 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LUNG_NSCLC_LUAD.
