WDR70

Across TCGA cell cohorts, WDR70 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR70-associated genes across cancer lineages are OR11G2, ADAM2, and F11. Each is linked with WDR70 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR70-to-partner and partner-to-WDR70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11G2 grouped by WDR70-low versus WDR70-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR70→partner) and Y-score (partner→WDR70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR11G2 →	+0.022	+4.643	<.001	.004	3	2
SKIN	ADAM2 →	+0.002	+3.700	<.001	.009	3	2
LARGE_INTESTINE	F11 →	+0.037	+2.560	<.001	.008	3	2
PANCREAS	SPATA31D3 →	+0.006	+5.614	<.001	.002	3	1
BONE	OR51I1 →	+0.303	+5.169	<.001	.004	3	1
BONE	OR10G3 →	+0.023	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

OR11G2 by WDR70 expression — LUNG_SCLC

Explore this box plot interactively →