UTP3 small subunit processome componentGenealiases: CRL1 · CRLZ1 · SAS10
Q-omics provides the consensus-scored UTP3 profile across patient tissues and cancer cell-line models. UTP3 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, UTP3 is differentially expressed in 11, with the highest sampling consensus in LIHC. Additionally, UTP3 protein abundance shows 31,241 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, LIHC, and LSCC as cancer lineages where UTP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UTP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UTP3 survival associations across molecular data types. UTP3 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UTP3 RNA expression–survival associations across cancer types. High UTP3 expression shows unfavorable associations in HNSC, UVM, KIRP, LIHC and ACC, but favorable associations in KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for UTP3 RNA expression.
This table summarizes UTP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 7. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for UTP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UTP3 shows lower tumor expression in THCA and BLCA and higher tumor expression in LIHC, COAD, STAD and HNSC. The LIHC box plot shows higher UTP3 RNA expression in tumor versus normal tissue (log2 FC = +0.580, t-test p < 0.001).
This table shows molecular features associated with UTP3 in patient tissues and cancer cell lines. In patient samples, UTP3 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, UTP3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and STOMACH.
