UTP3

Across TCGA patient cohorts, UTP3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP3-associated genes across cancer lineages are ASNS, Di-Ras3, and 14-3-3_beta. Each is linked with UTP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both UTP3-to-partner and partner-to-UTP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UTP3-low versus UTP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP3→partner) and Y-score (partner→UTP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.499	+2.000	<.001	.029	3	3
UCEC	Di-Ras3 →	-0.135	-2.169	.015	.003	3	2
UCEC	14-3-3_beta →	-0.094	-2.432	.013	.018	3	1
UCEC	eEF2 →	+0.347	+2.999	.009	.035	3	1
UCEC	EGFR_pY1068 →	-0.281	-3.584	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.089	-1.415	.046	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ASNS by UTP3 expression — UCEC

Explore this box plot interactively →