ubiquitin specific peptidase 25Genealiases: EIG19 · USP21
Q-omics provides the consensus-scored USP25 profile across patient tissues and cancer cell-line models. USP25 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, USP25 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, USP25 protein abundance shows 21,044 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, KICH, and GBM as cancer lineages where USP25 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP25 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP25 survival associations across molecular data types. USP25 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP25 RNA expression–survival associations across cancer types. High USP25 expression shows unfavorable associations in UVM and BLCA, but favorable associations in KIRC, SKCM, HNSC and ESCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for USP25 RNA expression.
This table summarizes USP25 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in KICH for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for USP25. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP25 shows lower tumor expression in KICH, UCEC, LUAD, BRCA and KIRC and higher tumor expression in LIHC. The KICH box plot shows higher USP25 RNA expression in normal versus tumor tissue (log2 FC = −1.365, t-test p < 0.001).
This table shows molecular features associated with USP25 in patient tissues and cancer cell lines. In patient samples, USP25 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, USP25 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
