USP25

Across TCGA patient cohorts, USP25 protein abundance is significantly associated with the protein abundance of many other proteins, with 21,044 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP25-associated proteins across cancer lineages are RASAL3, TRIM28, and SF3B6. Each is linked with USP25 in more than 6 cancer types. Because this analysis shows association rather than direction, both USP25-to-partner and partner-to-USP25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP25 versus RASAL3 in GBM, with a Pearson correlation of 0.43.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USP25→partner) and Y-score (partner→USP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RASAL3 →	+0.449	+0.200	<.001	<.001	3	7
GBM	TRIM28 →	-0.342	-0.148	<.001	<.001	3	7
GBM	SF3B6 →	-0.271	-0.142	<.001	<.001	3	6
OV	SNRPD2 →	-0.294	-0.257	.001	<.001	3	6
HNSC	CBX8 →	-0.427	-0.267	<.001	<.001	3	6
GBM	DOCK8 →	+0.514	+0.176	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,044 associations by consensus.

USP25 vs RASAL3 — GBM

Explore this scatter interactively →