USP25

Across TCGA pan-cancer cohorts, USP25 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where USP25 RNA is repressed in tumor relative to normal tissue. In most cancer types USP25 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and LUAD are the cancer types where USP25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.365	<.001	8	view →
UCEC	All	All	−1.034	<.001	6	view →
LUAD	Female	II,III,IV	−0.561	<.001	6	view →
BRCA	All	III,IV	−0.537	<.001	6	view →
LIHC	All	All	+0.371	.002	6	view →
KIRC	All	II,III,IV	−0.367	.001	6	view →
LUSC	Male	All	−0.741	<.001	5	view →
THCA	All	II,III,IV	−0.357	.006	5	view →
CHOL	All	All	+1.052	<.001	2	view →
HNSC	Male	All	−0.313	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP25–KICH

Open the KICH breakdown →