USP25

Across TCGA patient cohorts, USP25 mutation is significantly associated with the RNA expression of many other genes, with 3,238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP25-associated genes across cancer lineages are RNA5SP412, RNU6-275P, and CCL3. Each is linked with USP25 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP25-to-partner and partner-to-USP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by USP25-low versus USP25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP25→partner) and Y-score (partner→USP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.364	+1.345	<.001	.004	3	4
BLCA	RNU6-275P →	+0.151	+4.722	<.001	.003	3	3
UCEC	CCL3 →	+0.645	+1.373	<.001	<.001	3	3
UCEC	FEN1 →	+0.460	+1.373	<.001	<.001	3	3
UCEC	RAD51 →	+0.617	+1.632	<.001	<.001	3	3
READ	RNU6-710P →	+0.444	+4.421	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,238 associations by consensus.

RNA5SP412 by USP25 expression — UCEC

Explore this box plot interactively →