USP25

Across TCGA cell cohorts, USP25 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP25-associated genes across cancer lineages are OR4N4, OR2C1, and PRMT8. Each is linked with USP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP25-to-partner and partner-to-USP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by USP25-low versus USP25-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP25→partner) and Y-score (partner→USP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4N4 →	+0.028	+3.289	<.001	.009	3	2
LARGE_INTESTINE	OR2C1 →	+0.087	+3.426	.005	.007	3	2
BLOOD_Leukemia	PRMT8 →	+0.379	+3.824	<.001	.001	3	1
BLOOD_Leukemia	BMP5 →	+0.012	+3.771	<.001	.004	3	1
BLOOD_Leukemia	VAX1 →	+0.008	+3.450	<.001	.004	3	1
BLOOD_Leukemia	SLC9A4 →	+0.016	+4.147	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OR4N4 by USP25 expression — BLOOD_Leukemia

Explore this box plot interactively →