olfactory receptor family 2 subfamily C member 1Genealiases: OLFmf3 · OR2C2P
Q-omics provides the consensus-scored OR2C1 profile across patient tissues and cancer cell-line models. OR2C1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in SCLC. Among the 18 cancer types available for tumor–normal comparison, OR2C1 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, OR2C1 RNA expression shows 16,498 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight SCLC, KICH, and THYM as cancer lineages where OR2C1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR2C1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR2C1 survival associations across molecular data types. OR2C1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR2C1 RNA expression–survival associations across cancer types. High OR2C1 expression shows unfavorable associations in DLBC, but favorable associations in SCLC, PAAD, KIRC, BRCA and LUAD. The SCLC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SCLC as the clearest survival context for OR2C1 RNA expression.
This table summarizes OR2C1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for OR2C1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR2C1 shows lower tumor expression in KICH, KIRC, KIRP, THCA, UCEC and LUSC. The KICH box plot shows higher OR2C1 RNA expression in normal versus tumor tissue (log2 FC = −0.348, t-test p < 0.001).
This table shows molecular features associated with OR2C1 in patient tissues and cancer cell lines. In patient samples, OR2C1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, OR2C1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
