OR2C1

Across TCGA pan-cancer cohorts, OR2C1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated OR2C1 data layer compared with 6 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher OR2C1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated OR2C1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

SCLC, PAAD, and KIRC are the cancer types where OR2C1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	III,IV	0.835	0.380	<.001	62	view →
PAAD	OS	Median	II,III,IV	0.722	0.527	.013	44	view →
KIRC	OS	Quartile	All	0.734	0.580	.004	38	view →
BRCA	DFS	Median	III,IV	0.938	0.819	.002	37	view →
LUAD	DFS	Median	All	0.868	0.758	.005	34	view →
DLBC	DFS	Tertile	All	0.402	1.000	.011	27	view →
READ	DFS	Median	IV	0.390	0.763	.006	23	view →
PRAD	DFS	Quartile	All	0.923	0.804	.003	20	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	18	view →
HNSC	DFS	Median	IV	0.484	0.281	.001	16	view →
LUSC	DFS	Quartile	II,III,IV	0.823	0.633	.004	14	view →
LGG	DFS	Median	All	0.883	0.781	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

OR2C1–SCLC (OS)

Open the SCLC breakdown →