OR2C1

Across TCGA patient cohorts, OR2C1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2C1-associated genes across cancer lineages are Cyclin-B1, eIF4E, and FoxM1. Each is linked with OR2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2C1-to-partner and partner-to-OR2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OR2C1-low versus OR2C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2C1→partner) and Y-score (partner→OR2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.651	+2.459	.016	.020	3	2
UCEC	eIF4E →	+0.200	+2.459	.049	.020	3	1
UCEC	FoxM1 →	+0.286	+2.999	.022	.035	3	1
UCEC	mTOR_pS2448 →	-0.199	-2.302	.005	.034	3	1
UCEC	Notch1 →	+0.244	+3.013	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.493	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Cyclin-B1 by OR2C1 expression — UCEC

Explore this box plot interactively →