USP25

Across TCGA patient cohorts, USP25 protein abundance is significantly associated with the RNA expression of many other genes, with 13,623 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USP25-associated genes across cancer lineages are C1orf162, KIAA1549, and ALOX5. Each is linked with USP25 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP25-to-partner and partner-to-USP25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP25 versus C1orf162 in OV, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP25→partner) and Y-score (partner→USP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1orf162 →	+0.797	+0.242	.002	.005	3	6
HNSC	KIAA1549 →	-0.940	-0.275	.001	<.001	3	5
GBM	ALOX5 →	+0.962	+0.199	<.001	<.001	3	5
OV	PTPN22 →	+0.965	+0.238	<.001	.003	2	6
OV	FLI1 →	+0.993	+0.279	<.001	<.001	3	5
UCEC	PRDM8 →	+0.632	+0.213	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,623 associations by consensus.

USP25 vs C1orf162 — OV

Explore this scatter interactively →