USP25

Across TCGA patient cohorts, USP25 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP25-associated genes across cancer lineages are Cyclin-B1, PCNA, and ERK2. Each is linked with USP25 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP25-to-partner and partner-to-USP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by USP25-low versus USP25-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP25→partner) and Y-score (partner→USP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.620	+3.321	.003	.010	3	4
UCEC	PCNA →	+0.186	+1.643	.001	.002	3	3
UCEC	ERK2 →	+0.146	+1.925	.004	.004	3	2
SKCM	JNK_pT183_Y185 →	-0.175	-3.000	.013	.035	3	2
UCEC	Lck →	+0.131	+1.247	.016	.041	3	2
UCEC	mTOR_pS2448 →	-0.081	-1.427	.044	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Cyclin-B1 by USP25 expression — SKCM

Explore this box plot interactively →