TOX high mobility group box family member 4Genealiases: C14orf92 · KIAA0737 · LCP1 · MIG7
Q-omics provides the consensus-scored TOX4 profile across patient tissues and cancer cell-line models. TOX4 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TOX4 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, TOX4 protein abundance shows 22,584 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, THCA, and LSCC as cancer lineages where TOX4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TOX4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TOX4 survival associations across molecular data types. TOX4 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TOX4 RNA expression–survival associations across cancer types. High TOX4 expression shows unfavorable associations in ACC, BLCA and LIHC, but favorable associations in KIRC, SCLC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TOX4 RNA expression.
This table summarizes TOX4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for TOX4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TOX4 shows lower tumor expression in THCA, BLCA and COAD and higher tumor expression in HNSC, LIHC and CHOL. The THCA box plot shows higher TOX4 RNA expression in normal versus tumor tissue (log2 FC = −0.368, t-test p < 0.001).
This table shows molecular features associated with TOX4 in patient tissues and cancer cell lines. In patient samples, TOX4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, TOX4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
