TOX4

Across TCGA cell cohorts, TOX4 mutation is significantly associated with the RNA expression of many other genes, with 325 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOX4-associated genes across cancer lineages are OR2B3, CCDC134, and FZD3. Each is linked with TOX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX4-to-partner and partner-to-TOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B3 grouped by TOX4-low versus TOX4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX4→partner) and Y-score (partner→TOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR2B3 →	+0.020	+5.781	<.001	.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.776	+3.301	.002	.003	3	1
LARGE_INTESTINE	FZD3 →	+0.760	+3.067	.004	.009	3	1
LARGE_INTESTINE	ARMC1 →	+0.444	+3.067	.004	.009	3	1
LARGE_INTESTINE	SLC39A14 →	+1.002	+3.237	<.001	.003	3	1
LARGE_INTESTINE	FGFR1OP2 →	+0.568	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 325 associations by consensus.

OR2B3 by TOX4 expression — BREAST

Explore this box plot interactively →