TOX4

Across TCGA cell cohorts, TOX4 mutation is significantly associated with the mutation status of many other genes, with 3,934 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOX4-associated genes across cancer lineages are HINFP, OCA2, and ABCC3. Each is linked with TOX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TOX4-to-partner and partner-to-TOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINFP grouped by TOX4-low versus TOX4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX4→partner) and Y-score (partner→TOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HINFP →	+5.297	+5.297	.004	.004	1	4
BLOOD_Leukemia	OCA2 →	+2.975	+3.794	.006	.006	1	4
LARGE_INTESTINE	ABCC3 →	+2.310	+3.584	<.001	<.001	1	4
BLOOD_Leukemia	ILF3 →	+3.338	+4.083	.003	.003	1	4
LARGE_INTESTINE	DAB2IP →	+2.217	+2.635	.002	.002	1	4
LARGE_INTESTINE	DIP2A →	+3.632	+3.392	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,934 associations by consensus.

HINFP by TOX4 expression — BREAST

Explore this box plot interactively →