TOX4

Across TCGA cell cohorts, TOX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,391 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOX4-associated GO terms across cancer lineages are Regulation of proteasomal ubiquitin-dependent protein catabolic process, Endosomal transport, and Positive regulation of proteasomal protein catabolic process. Each is linked with TOX4 in more than 15 cancer types. Because this analysis shows association rather than direction, both TOX4-to-partner and partner-to-TOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal ubiquitin-dependent protein catabolic process grouped by TOX4-low versus TOX4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX4→partner) and Y-score (partner→TOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.072	+0.861	<.001	<.001	3	16
STOMACH	Endosomal transport →	+0.085	+0.982	<.001	<.001	3	15
STOMACH	Positive regulation of proteasomal protein catabolic process →	+0.077	+0.892	.001	<.001	3	15
LARGE_INTESTINE	Regulation of ubiquitin-dependent protein catabolic process →	+0.067	+0.882	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.072	+0.745	<.001	<.001	3	15
STOMACH	Cellular response to nutrient levels →	+0.075	+1.024	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,391 associations by consensus.

Regulation of proteasomal ubiquitin-dependent protein catabolic process by TOX4 expression — LARGE_INTESTINE

Explore this box plot interactively →