TOX4

Across TCGA patient cohorts, TOX4 mutation is significantly associated with the RNA expression of many other genes, with 1,848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX4-associated genes across cancer lineages are ESCO2, PRC1, and MRPL46. Each is linked with TOX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOX4-to-partner and partner-to-TOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESCO2 grouped by TOX4-low versus TOX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX4→partner) and Y-score (partner→TOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ESCO2 →	+0.639	+3.467	.001	.002	3	3
UCEC	PRC1 →	+0.715	+2.914	.001	.001	3	3
UCEC	MRPL46 →	+0.411	+2.660	<.001	<.001	3	3
LIHC	MIR8053 →	+0.514	+6.169	<.001	<.001	3	2
CESC	MTCO2P8 →	+0.067	+5.418	.001	.005	3	2
READ	RNU6-893P →	+0.733	+4.445	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,848 associations by consensus.

ESCO2 by TOX4 expression — UCEC

Explore this box plot interactively →