TOX4

Across TCGA pan-cancer cohorts, TOX4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TOX4 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TOX4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOX4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TOX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.355	0.911	.010	18	view →
LSCC	DFS	Quartile	All	1.000	0.878	.007	11	view →
PDAC	DFS	Median	All	0.868	0.727	.009	10	view →
GBM	DFS	Quartile	All	0.591	0.363	.023	4	view →
CCRCC	DFS	Median	II,III,IV	0.784	0.601	.031	3	view →
LUAD	OS	Median	II,III,IV	0.999	0.869	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TOX4–HNSC (DFS)

Open the HNSC breakdown →