DNA topoisomerase II binding protein 1Genealiases: Dpb11 · TOP2BP1
Q-omics provides the consensus-scored TOPBP1 profile across patient tissues and cancer cell-line models. TOPBP1 expression is associated with patient survival in 30 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TOPBP1 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, TOPBP1 protein abundance shows 27,853 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, KIRC, and LSCC as cancer lineages where TOPBP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TOPBP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TOPBP1 survival associations across molecular data types. TOPBP1 RNA expression shows survival associations in the most cancer types (30), followed by mutation status (8) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TOPBP1 RNA expression–survival associations across cancer types. High TOPBP1 expression shows unfavorable associations in ACC, MESO, LIHC, KICH and PAAD, but favorable associations in UCS. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TOPBP1 RNA expression.
This table summarizes TOPBP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for TOPBP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TOPBP1 shows higher tumor expression in KIRC, BLCA, HNSC, KIRP, LIHC and COAD. The KIRC box plot shows higher TOPBP1 RNA expression in tumor versus normal tissue (log2 FC = +0.825, t-test p < 0.001).
This table shows molecular features associated with TOPBP1 in patient tissues and cancer cell lines. In patient samples, TOPBP1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, TOPBP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
