TOPBP1

Across TCGA patient cohorts, TOPBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOPBP1-associated genes across cancer lineages are RNU6-579P, PGK1, and PKMYT1. Each is linked with TOPBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-579P grouped by TOPBP1-low versus TOPBP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-579P →	+0.360	+3.995	.001	.002	3	3
UCEC	PGK1 →	+0.549	+2.545	.002	<.001	3	3
UCEC	PKMYT1 →	+0.600	+2.403	<.001	<.001	3	3
UCEC	TRPM2 →	+0.469	+1.551	<.001	<.001	3	3
COAD	UQCRHP1 →	+0.348	+3.979	<.001	.006	3	2
READ	RN7SL66P →	+0.152	+4.925	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,095 associations by consensus.

RNU6-579P by TOPBP1 expression — LUAD

Explore this box plot interactively →